The only trouble I've ever had is either after wayyyy overdoing it the night before, or drinking
a dkm-ish strain (like Stone, Chief's jungle, etc.), but even in those cases the next-morning issues are mild.
I never have gotten bed-lock, just a little groggy for a while... but I can get a somewhat unhappy stomach for the
morning. Once I have some breakfast I'm fine. Never had a headache (from kava) either.
I always chase each shell with a few schlooks of plain water. Helps keep hydrated, and also flushes
out the ass-awful taste. A thin slice of fresh ginger root after each shell keeps the stomach pretty
happy too.